IMMUNE ANTIVIRAL RESPONSE OF FISH AGAINST RNA VIRUSES
Descripción
THE OBJECTIVE OF THIS PROJECT IS TO INCREASE OUR KNOWLEDGE ON THE ANTIVIRAL RESPONSE OF FISH AGAINST THE MAIN VIRAL FAMILIES THAT AFFECT MARINE AQUACULTURE IN THE MEDITERRANEAN COUNTRIES. PATHOGENIC VIRUSES POSSESS MECHANISMS TO EVADE OR LIMIT INNATE HOST DEFENSES, DISRUPT NORMAL CELLULAR PROCESSES, AND GAIN PREFERENTIAL TRANSCRIPTION AND TRANSLATION OF THEIR OWN GENES, THEREFORE, VIRUSES HAVE EVOLVED MANY STRATEGIES TO OVERCOME HOST DEFENSES. WE WILL TRY TO ADDRESS COMMON AND EXCLUSIVE RESPONSES AGAINST DIFFERENT PATHOGENIC RNA VIRUSES REPRESENTING CONSERVED ANTIVIRAL PATHWAYS THAT WE COULD PRIME TO ACHIEVE A BETTER PROTECTION AGAINST VIRUSES. THE INFLUENCE OF INTERNAL FACTORS, SUCH AS AN EXCESSIVE INFLAMMATORY REACTION OR THE MICROBIOME WILL BE ALSO STUDIED TO LEARN HOW WE CAN MODULATE (AND IMPROVE) THE ANTIVIRAL RESPONSES OF CULTURED FISH SPECIES, BOTH THE INNATE RESPONSES AND ALSO THE ADAPTIVE RESPONSES WITH THE AIM TO INCREASE THE EFFICACY OF THE VACCINES AGAINST THESE RNA VIRUSES.
