Biosystem & Bioprocesses Engineering
From mathematical modeling and computer-aided simulation to design, control and optimization of bioprocesses and biological systems.
The world around us can be explained to a great extent by understanding the systems that compose it and the processes that connect them.
The IIM-CSIC's Biosystem & Bioprocess Engineering group seeks to develop new methods and tools (mainly software) for process systems engineering, which enable the simulation, optimization and control of bioprocesses, such as those involved in food processing and preservation and in industrial biotechnology.
The group applies process systems engineering methods to improve the efficiency of key industrial processes, reducing their environmental impact and improving the quality and safety of their products.
Its focus is model identification, optimization, monitoring and robust control of non-linear dynamic systems, including distributed parameter systems (convection-diffusion-reaction). The group considers a broad spectrum of applications, namely fisheries management, food processing, quality and safety—including antimicrobial resistance—and industrial biotechnology.
- DATAMARE -
<p>Programa Ciencias Mariñas: Plataforma integrada de datos mariños</p>
Principal investigator:VeloLanchasAntónFunding body:El Programa de Ciencias Mariñas de Galicia es 1 de los 5 programas de Ciencias Marinas de los Planes Complementarios de I+D+I con las CCAA del Plan de Recuperación Transformación y Resilencia (NextGenerationEU).Funding for IIM-CSIC:112585€Go to project pageFromto - PreCalA -
<p>Programa Ciencias Mariñas: Ferramentas para a predición da calidade en productos da acuicultura</p>
Principal investigator:VilasFernándezCarlosFunding body:El Programa de Ciencias Mariñas de Galicia es 1 de los 5 programas de Ciencias Marinas de los Planes Complementarios de I+D+I del Plan de Recuperación Transformación y Resilencia. Financiado por FEMP/FEMPA.Funding for IIM-CSIC:100281€Go to project pageFromto - DigitAlg -
<p>Programa Ciencias Mariñas: Xemelgo dixital do cultivo de algas na acuicultura multitrófica integrada</p>
Principal investigator:BalsaCantoEvaFunding body:El Programa de Ciencias Mariñas de Galicia es 1 de los 5 programas de Ciencias Marinas de los Planes Complementarios de I+D+I del Plan de Recuperación Transformación y Resilencia. Financiado por FEMP/FEMPA.Funding for IIM-CSIC:122667€Go to project pageFromto - ATOPES -
<p>Programa Ciencias Mariñas: Aplicación de Tecnoloxías Innovadoras para a Obtención de Datos Pesqueiros</p>
Principal investigator:TaboadaAnteloLuisFunding body:El Programa de Ciencias Mariñas de Galicia es 1 de los 5 programas de Ciencias Marinas de los Planes Complementarios de I+D+I con las CCAA del Plan de Recuperación Transformación y Resilencia (NextGenerationEU).Funding for IIM-CSIC:137391€Go to project pageFromto - aCIDit -
<p>a-CIDiT - Modelos basados en datos y actualización de modelos para gemelos digitales</p>
Principal investigator:TaboadaAnteloLuisVilasFernándezCarlosFunding body:Ayuda PID2021-123654OB-C32 financiada por MCIN/AEI/10.13039/501100011033 y por la Unión Europea NextGenerationEU/PRTRFunding for IIM-CSIC:94200€Go to project pageFromto
- Pedreira, A.; Vázquez, J.A.; García, M.R. (2022) Kinetics of Bacterial Adaptation, Growth, and Death at Didecyldimethylammonium Chloride sub-MIC Concentrations Frontiers in Microbiology DOI:10.3389/fmicb.2022.758237
- Ovalle, J.C.; Vilas, C.; Antelo, L.T. (2022) On the use of deep learning for fish species recognition and quantification on board fishing vessels Marine Policy DOI:10.1016/j.marpol.2022.105015
- González, P.; Osorio, R.R.; Pardo, X.C.; Banga, J.R.; Doallo, R. (2022) An efficient ant colony optimization framework for HPC environments Applied Soft Computing Journal DOI:10.1016/j.asoc.2021.108058
- Otero-Muras I; Banga JR (2021) Synthetic Gene Circuit Analysis and Optimization " Computational Methods in Synthetic Biology" Humana Press / Springer ISBN:978-1-0716-0822-7
- Otero-Muras I; Banga JR (2021) Automated Biocircuit Design with SYNBADm " Synthetic Gene Circuits" Springer ISBN:978-1-0716-1031-2
- TFM - Andrea Arribas Jimeno (26/09/2022) Aplicabilidad de la tecnología de imágenes hiperespectrales (HSI) como método no invasivo para la evaluación de la calidad del pescado UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
- TFM - Artai Rodríguez Moimenta (19/07/2020) Desarrollo de un modelo de corte mecanístico que permita describir un proceso de fermentación mixta Universidad de Vigo (UVigo)
- TFG - Laura Honrubia Baamonde (11/07/2019) Optimization of Benzalkonium Chloride treatment in the disinfection of L. Monocytogenes in the Food Industry UNIVERSIDAD DE LLEIDA
- TFM - Pablo de la Torre Fernández (20/09/2018) Modelado del proceso de fermenatición vínica: co-cultivo de especies no convencionales Universidade da Coruña
- PhD - Alejandro López Núñez (18/07/2018) CONTRIBUTIONS TO MATHEMATICAL MODELLING AND NUMERICAL SIMULATION OF BIOFILMS UdC
- WASHTOP -
<p>Water Associated Safety Hazards in the Treatment of Produce</p>
Principal investigator:RodríguezGarcíaMíriamFunding body:European Food Safety Authority (EFSA)Funding for IIM-CSIC:80000€Go to project pageFromto
- Capacidades | Desarrollo de sistemas de control y optimización a nivel de la planta completa en la industria alimentaria
Modelado a múltiples escalas para flexibilizar la toma de decisiones y optimizar procesos complejos (p. ej., esterilización) basado en el control de la seguridad y calidad de los productos alimentarios mediante técnicas no invasivas (sensores de software, etc.).
- Capabilities | Threat assessment and critical control points along seafood value chains
Assessment and development of protocols to identify the most problematic areas and products in terms of microbial contamination and parasitic infestation along the value chain of seafood products.
- Capabilities | Development of bioprocesses (biorefineries) for the extraction of bioproducts and bioactive compounds from food industry by-products
Development of processes that allow extracting useful components of industrial interest from discards and food industry by-products and effluents. Biochemical characterization of useful components present in different kinds of fisheries products and by-products, such as skin collagen, visceral enzymes, chondroitin sulphate present in cartilage, chitin from crustacean shells and cuttlebone or protein hydrolysates obtained from muscle. Evaluation of potential applications of these compounds through the characterization of their biological activities (antioxidants, etc.) and functional properties for their use in different industries, such as biomedical, chemistry, cosmetic, food, etc.
- Capacidades | Desenvolvemento de sistemas de control e optimización a nivel da planta completa na industria alimentaria
Modelaxe a múltiples escalas para flexibilizar a toma de decisións e optimizar procesos complexos (p. ex., esterilización) baseado no control da seguridade e calidade dos produtos alimentarios mediante técnicas non invasoras (sensores de software, etc.).
- Capacidades | Evaluación de amenazas y puntos de control críticos en las cadenas de valor de los productos del mar
Evaluación y desarrollo de protocolos para identificar los puntos y productos más problemáticos en cuanto a contaminación microbiológica e infestación parasitaria a lo largo de la cadena de valor de los productos del mar.
- Software | Model-based design of smart active packaging systems with antimicrobial activity
Matlab code to perform simulations and optimize packaging design using natural antimicrobials (carvacrol) for hake (Merluccius merluccius). In addition, different polymers are considered as possible active packaging materials.
More information here.
- Software | DOTcvpSB: Matlab toolbox for Dynamic Optimization in Systems Biology
DOTcvpSB is a toolbox written in MATLAB that uses the control vector parameterization (CVP) method to handle continuous and mixed integer dynamic optimization problems. DOTcvpSB has been successfully applied to several problems in systems biology and bioprocess engineering.
More information here.
- Software | Fish-T-TaB Simulator: Temperature simulator for fish stored in tubs and boxes
This model was developed and applied by members of the EFSA Working Group on the transport/storage of fresh fishery products during the preparatory work on the BIOHAZ Scientific Opinion on the use of "tubs" for transporting and storing fresh fishery products (EFSA-Q-2019-00053). Heat transfer modeling was applied to estimate surface temperature of fish during the temperature-related processes of cooling and subsequently maintaining the chill temperature of the fish (‘cooling’ process) and/or maintaining the chill temperature (‘keeping’ process) for fish kept in ice (in boxes) versus in water and ice (in tubs) under similar transport/storage conditions.
More information here.
- Software | CRNreals: distinguishability analysis of biochemical reaction networks
A software toolbox that supports the distinguishability analysis of chemical reaction network (CRN) models.
More information here.
- Software | Kinetics of E. coli inactivation by benzalkonium chloride v1.0
This model and associated code was developed to optimize disinfection protocols and minimize bacterial resistance. This model was applied in the following journal article: Optimization of E. coli Inactivation by Benzalkonium Chloride Reveals the Importance of Quantifying the Inoculum Effect on Chemical Disinfection. Front. Microbiol., 26 June 2018. https://doi.org/10.3389/fmicb.2018.01259
More information and access to the code here.
